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61.
Chungwen Wei Eugene Storozynsky A. J. McAdam Kun-Yun Yeh Brian R. Tilton Richard A. Willis Richard K. Barth R. John Looney Edith M. Lord J. G. Frelinger 《Cancer immunology, immunotherapy : CII》1996,42(6):362-368
Human prostate-specific antigen (PSA) has a highly restricted tissue distribution. Its expression is essentially limited
to the epithelial cells of the prostate gland. Moreover, it continues to be synthesized by prostate carcinoma cells. This
makes PSA an attractive candidate for use as a target antigen in the immunotherapy of prostate cancer. As a first step in
characterizing the specific immune response to PSA and its potential use as a tumor-rejection antigen, we have incorporated
PSA into a well-established mouse tumor model. Line 1, a mouse lung carcinoma, and P815, a mouse mastocytoma, have been transfected
with the cDNA for human PSA. Immunization with a PSA-expressing tumor cell line demonstrated a memory response to PSA which
protected against subsequent challenge with PSA-expressing, but not wild-type, tumors. Tumor-infiltrating lymphocytes could
be isolated from PSA-expressing tumors grown in naive hosts and were specifically cytotoxic against a syngeneic cell line
that expressed PSA. Immunization with tumor cells resulted in the generation of primary and memory cytotoxic T lymphocytes
(CTL) specific for PSA. The isolation of PSA-specific CTL clones from immunized animals further demonstrated that PSA can
serve as a target antigen for antitumor CTL. The immunogenicity studies carried out in this mouse tumor model provide a rationale
for the design of methods to elicit PSA-specific cell-mediated immunity in humans.
Received: 4 April 1996 / Accepted: 31 May 1996 相似文献
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F N Bamford 《BMJ (Clinical research ed.)》1996,313(7058):672-673
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A. A. Gontcharov 《Hydrobiologia》1996,336(1-3):93-97
A survey of the freshwater algal flora of the Primorsky Region, Russian Far East, is presented. During more than 70 years
of investigations 1659 species (including varieties and forms 2276 taxa) belonging to 346 genera of different groups of algae
have been recorded from this territory. The Primorsky Region is rich in habitats attractive to algae-rivers, lakes, reservoirs,
and ponds. The details of the distribution of algae in different types of waterbodies have been examined. The algal flora
of the region is comparable to the areas, and its taxonomical structure is typical for Eurasia. From this territory some new
species and varieties have been described — Achnanthes chankensis, Cymbella ventricosa var. hankensis, Surirella alisoviana, and others. The flora includes some rare species — Fragilaria magocsyi, Perone dimorpha, and Heterothrix monochloron, and some endemics of Asia — Navicula scutelloides var. baicalensis, N. globulifera var. nipponica, Gomphonema sphaerophorum, and Surirella tientsinensis. 相似文献
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N. H. Russel A. E. Hunter A. Haynes E. M. Bessell 《BMJ (Clinical research ed.)》1994,308(6945):1715-1716